Blog - Kit LAL


Potential applications of the Horseshoe Crab in the development of health products

The Horseshoe Crab from the Atlantic, commonly known as Limulus polyphemus, has existed for more than 200 million years. It has been classified under the category Arthropods since the 19th century, and not under Crustaceans as it was first thought. This close relative of Arachnids has historically been harvested for...



The Role of LPS in the Progression of Diabetic Nephropathy

lps in the progression of diabetic nephropathy

Lipopolysaccharides (LPS) or bacterial endotoxins are associated with a large range of pathologies. Some of these are tumor necrosis, neuroinflammation, bacteriobilia, respiratory diseases, coronary artery diseases, neonatal necrotizing enterocolitis, neurodegenerative diseases, cystic fibrosis, autoimmune diseases and even male infertility, as we mentioned before. In this article, we will talk about another...



Male Infertility Caused by Bacterial Lipopolysaccharides

male infertility caused by lps

The spermatozoon is the male gamete whose function is to lead the DNA towards the egg (female gamete) and form a zygote that will later turn into the embryo and the fetus. Therefore, the sperm count is considered to be of great importance for public health primarily because it is...

Association of Bacterial Lipopolysaccharides in the Pathology of Alzheimer’s Disease

bacterial lipopolysaccharides in alzheimers disease

Gram-negative bacteria are reported as the predominant microorganisms in the normal human brain. In previous articles, we have discussed the mechanisms that lipopolysaccharide endotoxins (LPS) possess to cause neuroinflammation and its results. However, research has gone a little further, associating these molecules with the clinical appearance of neurodegenerative diseases like...

Immunomodulation by Bacterial Lipopolysaccharides

immunomodulation by bacterial lipopolysaccharides

Lipopolysaccharides (LPS) or bacterial endotoxins are a molecule that is amply found in the outer membrane of gram-negative bacteria, except for species of the Sphingomonas genus, which have glucosphingolipids instead. Although at high concentrations LPS can induce fever, increased heart rate, septic shock and death, at relatively low concentrations some...



Bile contamination or Bacteriobilia, a risk factor in post-operative complications

bile contamination caused by gram negative bacteria

Bacterial endotoxins, as we already discussed in previous reviews, constitute the lipid part of the lipopolysaccharide molecule, which forms the outer membrane of the gram-negative bacterial cell, and they are an important factor in the pathogenicity of the microorganism. They are responsible for potentially life-threatening diseases, such as cholera and...

Gram-negative bacteria: opportunistic infections in patients with HIV/AIDS

infections in hiv patients caused by gram negative bacteria

Based on recent estimates conducted by scientists from Israel and Canada, there is a ratio of about 1,3:1 between bacterial cells and human cells, with an uncertainty of 25% and a variation of 53% relative to a standard male population of 70 kg. The vast majority of these commensal bacteria...

Neuroinflammation caused by bacterial endotoxins

neuroinflammation caused by bacterial endotoxins

Lipopolysaccharide endotoxins or bacterial endotoxins are lipopolysaccharide molecules constituting the outer membrane of Gram-negative bacteria and they are released into the environment when cell lysis occurs. These molecules have a high level of toxicity in other organisms and therefore, they are called endotoxins. The damages that are produced in mammals...



Different environments where bacterial endotoxins can be found

environments where bacterial endotoxins can be found

Bacterial endotoxins originate from Gram-negative bacteria, which, after death, are released to the environment where they encounter lipopolysaccharides, which constitute their cell wall and which are highly toxic substances to other organisms . These endotoxins are considered to be the most frequently reported pyrogens. Bacterial endotoxins cause infections that can...

Treatment of sepsis caused by Gram-negative bacteria

treating sepsis caused by gram negative bacteria

The most common treatment for sepsis caused by bacteria, whether Gram-positive or Gram-negative, is the use of antibiotics. When sepsis is caused by Gram-negative bacteria, antibiotic therapies have the disadvantage of producing an increase in the bacterial endotoxin levels in the blood plasma of patients. The highest concentration of bacterial...