Pyrostar Endotoxin specific reagents

Check out the new PYROSTAR™ ES-F line for the detection of bacterial endotoxin

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Endotoxin-free accessories

Check out our catalog of LAL Accessories

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Anywhere in the world

Wako is there to support your endotoxin testing needs

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Toxinometer® Measurement System

The Toxinometer® ET-6000 is our new computer-operated kinetic incubating tube reader

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About Wako's LAL Division

Long recognized as a world-renowned supplier of high purity chemicals and reagents, Wako Chemicals USA, Inc continues to maintain a proud history of product quality and customer service through the establishment of our LAL Division, and the introduction of our new PYROSTAR™ ES-F line for the detection of bacterial endotoxin.

As an FDA licensed facility, Wako Chemicals USA, Inc. – LAL Division is committed to ensuring that our production site and LAL reagents comply with all the rules, regulations, and quality standards set forth by FDA for current Good Manufacturing Practices (cGMP’s)

Horseshoe Conservation

U.S. Fish and Wildlife ServiceWako Chemicals USA, Inc. is very much concerned with maintaining the viability of the horseshoe crab population. We are dedicated to following practices that ensure the careful handling and good quality of crabs used for LAL manufacture that both minimize injury and protect this invaluable species. After bleeding, the crabs are returned the next day by our fisherman to the same waters where they were collected. To assist in the collection of data for crab conservation studies, Wako USA participates in a horseshoe crab tagging and monitoring program coordinated by the U.S. Fish and Wildlife Service. For more information, visit Wako´s Commitment For Horseshoe Crab Conservation

 

 

 

 

About Our Products

LAL Reagent Kit

LAL Reagents

Welcome to our LAL Reagents section. On this page, you will be able to browse through our gallery of Limulus Amebocyte Lysate products for the detection of Gram-negative bacterial endotoxins. Choose from our different detection methods and request quotes now!

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LAL Accessories for Bacterial Endotoxin Test

LAL Accessories

To complement our limulus amebocyte lysate (LAL) reagent product line, our trademark PYROSTAR offers accessories, kits and solutions for use in the different endotoxin detection assays. View Gel Clot Reaction Tubes, Lysate Reagent Water, Toxinometer® ET-6000 Series and more.

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LAL Distributors

LAL Distributors

Our FDA-licensed LAL reagents and related accessories are available from our network of distributors around the world. Search for your location and find contact details of our resellers in your country. Are you interested in becoming a distributor of our LAL reagents? Contact Us Now.

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Featured Products

Kit of 4 PYROSTAR™ ES-F (5.2 ML) with CSE

Kit of 4 PYROSTAR™ ES-F (5.2 ML) with CSE

PYROSTAR™ ES-F Multi Test Vial (2.0 mL and 5.2 mL) with Control Standard Endotoxin (CSE) Intended Use: Limulus...

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Kit of 100 PYROSTAR™ ES-F (5.2 ML) without CSE

Kit of 100 PYROSTAR™ ES-F (5.2 ML) without CSE

PYROSTAR™ ES-F Multi Test Vial (2.0 mL and 5.2 mL) Intended Use: Limulus amebocyte lysate (LAL) is...

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Limulus Color KY Series

Limulus Color KY Series

The Limulus Color KY Series includes both a multi-test kit and a single-test kit, each designed...

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Pyrostar ES-F Plate With CSE

Pyrostar ES-F Plate With CSE

PYROSTAR™ ES-F/Plate Multi Test Vial (2.0 mL and 5.2 mL) with Control Standard Endotoxin (CSE) Intended Use: Limulus...

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BioClean® Series

BioClean® Series

Wako's premiere collection of endotoxin-free pipette tips, test tubes and caps designed for worry free endotoxin testing...

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Control Standard Endotoxin

Control Standard Endotoxin

Our Control Standard Endotoxin is a lyophilized product composed of 500ng of endotoxin, purified from E....

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Gel Clot Reaction Tubes

Gel Clot Reaction Tubes

Our Gel Clot Reaction Tubes are made of high quality Borosilicate glass and certified free of...

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Toxinometer ET-6000 Series

Toxinometer ET-6000 Series

The Toxinometer® ET-6000 is our new computer-operated kinetic incubating tube reader, which is exceptionally user-friendly and easily...

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Blog

Treatment of sepsis caused by Gram-negative bacteria
Treatment of sepsis caused by Gram-negative bacteria

The most common treatment for sepsis caused by bacteria, whether Gram-positive or Gram-negative, is the use of antibiotics. When sepsis is caused by Gram-negative bacteria, antibiotic therapies have the disadvantage of producing an increase in the bacterial endotoxin levels in the blood plasma of patients. The highest concentration of bacterial

The Use of Toxinometer ET-6000 in LAL test
The Use of Toxinometer ET-6000 in LAL test

Toxinometer® ET-6000 is the new equipment developed by the company Wako for the reading of tubes in which the LAL (Limulus Amebocyte Lysate) test is performed for the quantification of bacterial endotoxins in a sample. Today the LAL test is considered to be the most effective method for the detection

Mechanisms of cellular stimulation by bacterial endotoxins
Mechanisms of cellular stimulation by bacterial endotoxins

Bacterial endotoxins are released into the host organisms when Gram-negative bacteria reproduce or die. The outer membrane of Gram-negative bacteria is formed by two layers organized in an asymmetric manner. The main components of the outer part of these two layers are the lipopolysaccharides (LPS), also known as bacterial endotoxins

The relation of endotoxins with tumor necrosis
The relation of endotoxins with tumor necrosis

The causes of hemorrhagic tumour necrosis were an enigma to scientists until the middle of the last century. A study signed by Carswell et al, which stated that one of the indirect causes of tumour necrosis were bacterial endotoxins, was published in 1975. The authors of this study showed that