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Where and why is the LAL test performed?

Jan 23, 2018
where and why is the lal test performed

The LAL test (acronym for Limulus Amebocyte Lysate) is a test for the determination of bacterial endotoxins, which uses an Amebocyte Lysate of the Limulus crab. In this test, the reactions which occur in the Amebocyte Lysate as a result of a defence mechanism of the crab in the presence...

By: Lisa Komski
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Reagents and Accessories for the Limulus Amebocyte Lysate Test (LAL)

Jan 8, 2018
reagents and accessories for the limulus amebocyte lysate test

The Limulus Amebocyte Lysate Test (LAL) is a method for the detection and quantification of bacterial endotoxins that is widely used by the pharmaceutical and biotechnology industry. The biochemical principle of the test is based on the clotting reaction of the hemolymph of the _Limulus polyphemus_, commonly known as the...

By: Lisa Komski In: Kit LAL
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Potential applications of the Horseshoe Crab in the development of health products

Nov 9, 2017
the horseshoe crab and its importance for health

The Horseshoe Crab from the Atlantic, commonly known as _Limulus polyphemus, _has existed for more than 200 million years. It has been classified under the category Arthropods since the 19th century, and not under Crustaceans as it was first thought. This close relative of Arachnids has historically been harvested for...

By: Lisa Komski In: Kit LAL
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The Role of LPS in the Progression of Diabetic Nephropathy

Sep 26, 2017
lps in the progression of diabetic nephropathy

Lipopolysaccharides (LPS) or bacterial endotoxins are associated with a large range of pathologies. Some of these are tumor necrosis, neuroinflammation, bacteriobilia, respiratory diseases, coronary artery diseases, neonatal necrotizing enterocolitis, neurodegenerative diseases, cystic fibrosis, autoimmune diseases and even male infertility, as we mentioned before. In this article, we will talk about another...

By: Lisa Komski In: Kit LAL
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Male Infertility Caused by Bacterial Lipopolysaccharides

Sep 1, 2017
male infertility caused by lps

The spermatozoon is the male gamete whose function is to lead the DNA towards the egg (female gamete) and form a zygote that will later turn into the embryo and the fetus. Therefore, the sperm count is considered to be of great importance for public health primarily because it is...

By: Lisa Komski In: Kit LAL
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Association of Bacterial Lipopolysaccharides in the Pathology of Alzheimer’s Disease

Jun 30, 2017
bacterial lipopolysaccharides in alzheimers disease

Gram-negative bacteria are reported as the predominant microorganisms in the normal human brain. In previous articles, we have discussed the mechanisms that lipopolysaccharide endotoxins (LPS) possess to cause neuroinflammation and its results. However, research has gone a little further, associating these molecules with the clinical appearance of neurodegenerative diseases like...

By: Lisa Komski In: Kit LAL
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Immunomodulation by Bacterial Lipopolysaccharides

May 31, 2017
immunomodulation by bacterial lipopolysaccharides

Lipopolysaccharides (LPS) or bacterial endotoxins are a molecule that is amply found in the outer membrane of gram-negative bacteria, except for species of the _Sphingomonas_ genus, which have glucosphingolipids instead. Although at high concentrations LPS can induce fever, increased heart rate, septic shock and death, at relatively low concentrations some...

By: Lisa Komski In: Kit LAL
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Bile contamination or Bacteriobilia, a risk factor in post-operative complications

Apr 5, 2017
bile contamination caused by gram negative bacteria

Bacterial endotoxins, as we already discussed in previous reviews, constitute the lipid part of the lipopolysaccharide molecule, which forms the outer membrane of the gram-negative bacterial cell, and they are an important factor in the pathogenicity of the microorganism. They are responsible for potentially life-threatening diseases, such as cholera and...

By: Lisa Komski In: Kit LAL
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Gram-negative bacteria: opportunistic infections in patients with HIV/AIDS

Mar 24, 2017
infections in hiv patients caused by gram negative bacteria

Based on recent estimates conducted by scientists from Israel and Canada, there is a ratio of about 1,3:1 between bacterial cells and human cells, with an uncertainty of 25% and a variation of 53% relative to a standard male population of 70 kg. The vast majority of these commensal bacteria...

Neuroinflammation caused by bacterial endotoxins

Jan 25, 2017
neuroinflammation caused by bacterial endotoxins

Lipopolysaccharide endotoxins or bacterial endotoxins are lipopolysaccharide molecules constituting the outer membrane of Gram-negative bacteria and they are released into the environment when cell lysis occurs. These molecules have a high level of toxicity in other organisms and therefore, they are called endotoxins. The damages that are produced in mammals...

By: Lisa Komski In: Kit LAL
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